PhD from Rockefeller University
MS and DVM, National Taiwan University
Auditory circuits offer an excellent system to study synaptogenesis in the CNS because they contain two types of extraordinarily large synapses with well-characterized electrophysiological properties. Our lab has identified the transcription factor MafB as a potential master regulator of synaptic development in auditory circuits based on its expression pattern, functions in other developing systems, and ability to control the expression of known synaptic molecules.
I test this hypothesis by creating and analyzing MafB conditional knock-outs and by identifying MafB target genes using genome-wide strategies. Studying MafB function in synapse development of auditory circuits may provide the opportunities to understand the molecular mechanisms of synaptogenesis and identify novel deafness or autism susceptibility genes.